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Agmatine


PRIMAFORCE AGMATINE
            
AGMATINE SULPHATE POWDER

  • Increase Pumps

Agmatine is a relatively new compound in the supplement market that is gaining popularity. So why is Agmatine useful and why do some refer to it as a “Super Arginine”?

What is Agmatine?

Agmatine is a metabolic byproduct of Arginine produced through a process called decarboxylation. Agmatine is basically Arginine with the carboxylic acid end removed. Agmatine produces the byproducts Guanidino-butyladehyde and the polyamines putruscene, spermine, and spermidine which are involved in cell growth. Agmatine is found in tissues throughout the body and is synthesized and stored in astrocytes, glial cells in the brain and spinal cord, which provide structural and metabolic support to the nervous system among other actions. Agmatine acts as a neurotransmitter and neuromodulator with a vast array of actions in the body.

What does Agmatine do?

  • Stimulates the release of insulin and uptake of calcium in pancreatic cells leading to improved insulin sensitivity.
  • Binds to Imidazoline Receptors providing analgesia and assisting in pain management.
  • Binds to Alpha2-Adrenergic and Imidazoline Receptors of endothelial cells increasing Nitric Oxide (NO) production thereby decreasing blood pressure.
  • Inhibits monoamine oxidase (MAO) leading to antidepressant effects. Antagonist of the N-Methyl-D-Aspartate (NMDA) receptor providing a potential neuroprotective role.
  • Simulates the release of catecholeamines (norepinephrine, epinephrine, and dopamine) assisting in stress management.
  • Increases release of GnRH from the hypothalamus, stimulating secretion of LH/FSH which could increase testosterone production in the testes.
  • Inhibits Nitric Oxide Synthase (NOS), specifically iNOS and nNOS, leading to increased potential muscle pumps.
  • Improve kidney function through stimulation of the Glomerular Filtration Rate (GFR) Agmatine provides many health benefits, but of interest to fitness enthusiasts it provides: Improved insulin sensitivity (which can assist in improving body composition)
  • Potential to increase testosterone production
  • Assists in stress reduction Increase in muscle pumps

How Should I use Agmatine?

Dosages of 1.5- 3.5 grams per day of Agmatine Sulfate have been shown to be safe in humans, though 3.5 grams caused mild diarrhea and nausea. The generally agreed upon dosing recommendation for Agmatine for physique-related benefits is 1,000mg first thing in the morning on an empty stomach.



References

Agostinelli, E., M. P. Marques, et al. (2010). "Polyamines: fundamental characters in chemistry and biology." Amino Acids 38(2): 393-403. Ahn, S. K., S. Hong, et al. (2011). "Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase." Brain Res 1373: 48-54. Arndt, M. A., V. Battaglia, et al. (2009). "The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis." Am J Physiol Cell Physiol 296(6): C1411-1419. Berkels, R., D. Taubert, et al. (2004). "Agmatine signaling: odds and threads." Cardiovasc Drug Rev 22(1): 7-16. Gao, Y., B. Gumusel, et al. (1995). "Agmatine: a novel endogenous vasodilator substance." Life Sci 57(8): PL83-86. Haenisch, B., I. von Kugelgen, et al. (2008). "Regulatory mechanisms underlying agmatine homeostasis in humans." Am J Physiol Gastrointest Liver Physiol 295(5): G1104-1110. Halaris, A. and J. Plietz (2007). "Agmatine : metabolic pathway and spectrum of activity in brain." CNS Drugs 21(11): 885-900. Iizuka, Y., S. Hong, et al. (2010). "Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress." Braz J Med Biol Res 43(4): 356-358. Jo, I., C. Han, et al. (2010). "Low levels of plasma agmatine in the metabolic syndrome." Metab Syndr Relat Disord 8(1): 21-24.








PrimaForce AGMATINE at a Glance: Agmatine provides all the potential benefits of Arginine and much more. Agmatine delivers more than just muscle pumps, it delivers beneficial effects that can lead to overall better health and body composition.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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