PRIMAFORCE ARTICLES
Scivation Sesamin + Primaforce Max CLA: Controlling Your Body Fat
Derek Charlebois
The norm in bodybuilding is to alternate between periods of cutting and bulking, or simply put periods of losing fat while trying not to lose muscle and periods of gaining muscle commonly along with fat. I myself hate dieting for 20 weeks for a competition only to quickly regain the fat I loss as soon as I raise my caloric intake. Because of this, I try to keep my body fat percentage under control while bulking. Sesamin has proved to be a godsend in regards to keep my body fat under control while bulking. Like everyone else reading this article, I am always looking for ways to improve my results. The combination of Sesamin + CLA looks to be a way to do just that.
Scivation Sesamin
Sesamin is a lignan isolated from sesame seeds. A lignan is a molecule that combines with another entity acting as an “activator.” In the case of sesamin, it binds to and activates a receptor called Peroxisome Proliferator-Activator Receptor Alpha (PPARalpha). Sesamin has been shown to be a potent PPARalpha activator [1].
The PPAR receptor family is divided into three subgroups: alpha, beta/delta, and gamma. PPARalpha is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis. Activation of PPARalpha increases gene expression of the fatty acid oxidation enzymes and decreases gene expression of lipogenic enzymes.
Of vital important, Sesamin increases the expression of the mitochondrial enzyme carnitine palmitoyl transferase (CPT), among other enzymes [2]. CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them. Increasing the expression of CPT, along with other enzymes involved in beta-oxidation, will allow more fatty acids to be transported into the mitochondria where they can be oxidized.
In addition to increasing the oxidation of fat, Sesamin supplementation has also been shown to decrease lipogenesis (fat storage) by decreasing lipogenic enzymes in the liver. Sesamin has been shown to decrease lipogenic the gene expression of sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase, among other lipogenic enzymes [3], which means less fat is esterifized in the liver and therefore less fat is stored in adipose tissue (fat cells). So Sesamin works in two ways to make you lean (and keep you lean): increasing fat oxidation and decreasing fat storage.
Primaforce MAX CLA
Conjugated Linoleic Acid (CLA) is a mix of isomers of linoleic acid (commercially sold as a 50:50 mix of cis-9, trans-11 and trans-10, cis-12 isomers). Studies done on humans have shown decreased body fat and/or increased lean mass (though results are mixed). CLA is believed to influence body composition through regulation of lipid metabolism.
Studies have shown CLA to inhibit transcription of enzymes involved in de novo fatty acid synthesis/lipogenesis, desaturation of fatty acids, and triglyceride synthesis [4]. It is believed that CLA decreases the activation of PPARgamma, resulting in the attenuation of fat cell differentiation. In mice, CLA supplementation has been shown to decrease adipocyte number and size as well as cause apoptosis (cell death) of adipocytes [4] and researchers believe CLA to have similar properties in humans.
Scivation Sesamin + Primafoce MAX CLA Supplmentation
The combination of Sesamin + CLA should prove very potent for fat loss or fat gain prevention. Supplementing with CLA will cause a decrease in triglyceride uptake by adipocytes and lipogenesis/fat storage, but if these fatty acids are not oxidized, they will build up in the blood and liver leading to insulin resistance. By adding Sesamin into the mix, fat oxidation will be increased (very strongly in the liver), resulting in the oxidation of the elevated fatty acid concentration caused by CLA as well as working synergistically with CLA to decrease fat storage. The combination of Sesamin + CLA attacks fat oxidation and storage from multiple angles, resulting in less stored body fat [5].
Stack Directions
Take 1 cap Scivation Sesamin + 1-2 caps Primaforce Max CLA three times a day with meals.
References:
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JARQ 37 (3), 151 – 158 (2003)’
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J Agric Food Chem. 2001 May;49(5):2647-51
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Biochim Biophys Acta. 2001 Nov 30;1534(1):1-
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J Lipid Res. 2003 Dec;44(12):2234-41. Epub 2003 Aug 16
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Biosci Biotechnol Biochem. 2001 Nov;65(11):2535-41.
Primaforce Ultimate Joint Health Stack—Elastamine + Cissus
Joint pain and injuries often cause roadblocks in ones progress to their ultimate goal. Nothing is more frustrating than suffering an injury when you are progressing well and having to take time off. Minor nagging injuries or joint pain can keep you from training full throttle in the gym, hampering your progress. It is time to heal these injuries and even prevent them from happening with the Primaforce Ultimate Joint Health Stack—Elastamine + Cissus.
Primaforce Elastamine
Elastamine contents the proven joint health supplments Glucosamine Sulfate, MSM (Methylsulfonylmethane), Chondroitin Sulfate, and Bromelain. Glucosamine aids in repairing and lubricating the cartilage that surrounds joints. It has been shown to regenerate cartilage cells and decrease joint pain. Chondroitin Sulfate is a component of cartilage that provides structure to the cartilage and allows nutrients to pass through it. Supplementing with Chondroitin Sulfate can increase the elasticity and nutrient deliver to cartilage, leading to healthier cartilage. Supplemental MSM provides materials needed to rebuild connective. The sulfur from MSM can be used to repair collagen. Bromelain is a protein digesting enzyme that increases immune function and is an anti-inflammatory; both properties are very beneficial to joint health.
Primaforce Cissus
Cissus Quadrangularis, Cissus for short, is a plant common to India and African, where is has been used for centuries in treating bone fractures and other diseases. More recently, research has shown Cissus to aid in improving body composition, overall health and wellness, and more importantly to the issue at hand, joint and bone health. Primaforce Cissus is a high potency extract that contains 40% ketosterones. Ketosterones are the compounds in the Cissus plant that are responsible for its beneficial effects. Taking Primaforce Cissus can help heal joint injuries and even prevent them from happening.
Elastamine + Cissus
Combining Primaforce Elastamine and Cissus creates the ultimate joint health stack. This stack addresses joint health and intregity though multiple pathways, leading to stronger, more stable joints and connective tissue. If you are experiencing joint pain or an injury or want to help prevent potential injuries from occurring the Primaforce Ultimate Joint Health Stack is perfect for you.
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